Dr. Hofstein came to Toronto from Israel in 2009 to assume the position of President & CEO of a newly formed organization called MaRS Innovation (recently renamed as Toronto Innovation Acceleration Partners, TIAP). At this position, Dr. Hofstein led to the creation of over fifty start-up companies primarily in the healthcare space. Among the companies of primary note are Triphase, Fibrocor and Notch Therapeutics in which Dr. Hofstein has been a cofounder and a director. In addition, Dr. Hofstein is a member of the board of several not-for-profit organization in Quebec and Ontario. 

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Prior to coming to Canada, Dr. Hofstein served as the President & CEO of Hadasit (the tech transfer company of Hadassah, Jerusalem) and the chairman of Hadasit Bioholding (a holding company listed on the Tel-Aviv Stock Exchange). One of the companies Dr. Hofstein cofounded and joined as a director is BiolineRx, an Israeli biotech company listed on NASDAQ. 

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Dr. Hofstein received his Ph.D. from the Weizmann Institute of Science (Rehovot, Israel) and his postdoctoral training at Harvard Medical School. Dr. Hofstein also had a long tenure in the IDF and retired as a colonel after serving in the reserve troops for over twenty years.